The Jaguars have long been considered the NFL's preferred choice to move to London but Shad Khan has poured cold water over the suggestion.
The prospect of a London-based NFL team has never been more realistic, but there are a number of hurdles still to clear.
The fourth and final game in London sees two AFC South rivals collide when the Houston Texans take on the Jacksonville Jaguars.
Week 9 of the NFL begins on Thursday when the San Francisco 49ers look to make it 8-0 when they take on the Cardinals in Arizona.
The Bengals have got off to their worst start since 2008 and are two games ahead from equalling their worst-ever start, but could they land the number one overall pick?
The NFL returns to London as the Rams look to continue their recovery when they take on a Cincinnati team still looking for its first win of the season.
The Carolina Panthers make their first trip to London looking for a fourth consecutive win, while Tampa needs a win against its NFC South rivals.
The Oakland Raiders became the first team to win an NFL game at the Tottenham Hotspur Stadium on Sunday and three more games are scheduled in London over the next four weeks.
Could this pave the way for an NFL team in London?