Nadal takes on 2014 U.S. Open winner Marin Cilic while Osaka plays No. 13 seed Belinda Bencic on Monday.
Federer takes on Britain's Dan Evans, while Djokovic faces American qualifier Denis Kudla on Friday evening.
Coco Gauff plays Hungary's Timea Babos, while Rafael Nadal takes on Australia's Thanasi Kokkinakis on Thursday.
The world No. 1 and the world No. 3 are both in action on Wednesday, as are the Williams sisters.
Rafael Nadal and Coco Gauff are both in action on Tuesday as the first round of the U.S. Open is completed.
The world number one takes on the number 23 seed as he looks for a second consecutive Wimbledon final.
Federer and Nadal will renew their rivalry on Centre Court on Friday, 11 years after they last met in an epic final.
Roger Federer and Rafael Nadal go head-to-head at Wimbledon for the first time in 11 years on Friday.
Men's tennis's Big Three have looked in imperious form so far and are all in action in the quarterfinals at Wimbledon on Wednesday.
Federer plays Italy's Matteo Berrettini, Nadal takes on Portugal's Joao Sousa and Djokovic faces France's Ugo Humbert.
Tennis's new teenage sensation plays Slovenia's Polona Hercog on Friday as she makes her first appearance on Centre Court.
The 15-year-old American looks to continue her Wimbledon fairy tale after eliminating Venus Williams.
The 133rd edition of the oldest Grand Slam tournament begins on Monday as Federer looks for a ninth Wimbledon crown.
The 133rd edition of the oldest Grand Slam tournament gets underway on Monday as Novak Djokovic and Angelique Kerber look to defend their titles.
The semifinals of both the men's and the women's tournament are scheduled for Friday, June 7 as Rafael Nadal and Roger Federer go head-to-head again.
The American beat hometown favorite Andy Murray in a Wimbledon quarterfinal on Wednesday.
McEnroe has already been in trouble for comments he made this summer.
The big four have dominated the men's singles game at SW19.
Murray begins his defense on Monday in London.
The two men are playing for a place in the semifinal at Roland Garros.
Djokovic faces Dominic Thiem in the quarterfinal at Roland Garros.
Tennis' only clay major is finally attempting to modernize.
The Briton has suffered with injury this year.
The Swiss wants to concentrate on the grass-court season.
They last met in a Grand Slam final in 2011.
Novak Djokovic lost his last Grand Slam match as a man in his 20s, opening up more questions about how he'll fare in his next decade.
Djokovic was the second seed in Melbourne.
Federer has not played a Grand Slam since Wimbledon 2016.