Ohio State looks to improve to 7-0 when it takes on Northwestern in a rematch of last year's Big Ten Championship Game.
Top-ranked Alabama hosts Tennessee, while No. 2 ranked LSU and No. 3 ranked Clemson are on the road in Week 8.
Clemson and Alabama are back in action this weekend after a bye in Week 6 in a jam-packed weekend featuring five meetings between Top 25-ranked teams.
Two top-25 ranked teams meet in Ohio on Saturday, with the No.4-ranked Buckeyes looking to improve to 6-1
Clemson looks to extend its winning streak to 20 games when it plays North Carolina on the road on Saturday.
The Buckeyes should move to 4-0 this weekend, when they host Miami in their final nonconference game of the season.
Tua Tagovailoa, Jalen Hurts and Joe Burrow have emerged as the runaway favorites for the award after the first three games of the season.
Week 4 features three matchups between Top-25 ranked teams, including a major test for Georgia, which takes on Notre Dame.
The Buckeyes and the Hoosiers have both won their two opening games but for one team their perfect record will come to and end on Saturday.
No. 1-ranked Clemson travels to Syracuse, while No.2-ranked Alabama takes on South Carolina on the road.
The Buckeyes look to improve their record to 2-0 when they take on Ohio rivals Cincinnati Bearcats on Saturday afternoon.
Defending champion Clemson hosts No. 12 Texas A&M, while No. 2 Alabama and No. 3 Georgia take on New Mexico State and Murray State.
The Ryan Day era at Ohio State gets underway on Saturday when the Buckeyes welcome Florida Atlantic in the first game of the season.
The college football season begins in earnest on Thursday, and Clemson and Alabama again look favorites to go head-to-head for the national title.
Clemson is the favorite to retain its national title this season, closely followed by Alabama and Georgia.
"I don't know what he's talking about," Dayton Mayor Nan Whaley said as she read Donald Trump's tweets attacking her.
The 20-year-old announced on Twitter he was transferring to the Hurricanes.
The 54-year-old led the Buckeyes to an 82-9 record during his seven years in Columbus.
An assistant coach allegedly ordered sex toys to an athletic office, took photos of himself having sex with an OSU staffer in the offices and took pictures of his penis inside the White House when the team visited in 2015.
This one is going to be talked about for a long time.
The Tide need help to make the postseason.
Nick Saban's team won't be in the SEC Championship Game.
Harbaugh has been linked with the Bears.
Abdul Razak Artan, who attacked his fellow students at Ohio State University, may have been inspired by the late Al-Qaeda-linked cleric, Anwar al-Awlaki, an FBI official said on Wednesday.
The Somali attacker had criticized the media for its portrayal of Muslims.
Eddie George is poised to perform the role of Billy Flynn in the musical 'Chicago.'