Former CNN host Morgan interviewed President Trump during his U.K. state visit in June.
"Oprah alone checks all the boxes that a Democrat needs to win," Maher said on his HBO show Friday night.
The Instagram user suggested Winfrey should have paid off the student loan debt of the graduates at Colorado College, where she gave a commencement speech.
Tickets to the commencement were limited to graduates and their guests.
Winfrey recently spoke to the alleged sexual abuse victims of Michael Jackson featured in the Leaving Neverland documentary for an HBO special.
The talk show host and philanthropist, who rarely makes political endorsements, explained in an impassioned speech why she decided to support Georgia gubernatorial candidate Stacey Abrams.
High-profile users from Trump to Oprah suffered huge losses following a cull of suspicious accounts.
Politics is "not a clean business," Oprah said.
Among Republicans who favored another candidate, there was no consensus on a new contender.
Oprah's interview with Stephen Colbert was crashed by a higher power.
Biden did not run for president in 2016 because he and his family were grieving over the death of their son.
She got emotional birthday wishes from Ava DuVernay, Reese Witherspoon, Bernice King and more.
Oprah's enormous following is "like a religious movement," says a professor who studies charisma in politics. Yes, she could really win a presidential race.
Harrison Ford could be Winfrey's potential Secretary of Defense.
The TV host suggested the media were sheep who would back Oprah.
"She would absolutely do it."