The Premier League champions-elect are 90 minutes away from a first appearance in the Champions League final.
City became the first team in Premier League history to reach 100 points.
City let a two-goal lead slip in the Manchester derby on Saturday (April 7).
Pep Guardiola could win his first Premier League title against Manchester United.
The circumstances surrounding the fixture may be similar to last year, but this season the league is very different.
The league leader is looking to get even stronger in the new year.
Many regard it as the most exciting league in world football.
The Manchester United manager is furious after Gareth Southgate played injured Phil Jones.
Mourinho's United is already eight points behind City in the Premier League.
Arsenal travels to the Etihad Stadium, where Alexis Sanchez may wish he'd moved to.
The Manchester City manager looks set to bolster his squad even further in January.
Manchester City offered Arsenal £60 million for Sanchez six weeks ago, but now it'll accept a third of that.
In the summer, the Portuguese coach mocked Manchester City paying £54 million for Kyle Walker.
The German playmaker's contract expires at the end of the season, but he looks set to stay in north London.
The world transfer record was broken this summer, when PSG paid £199 million for Neymar.
The two clubs have begun the Premier League season at pace, and will also battle it out in the transfer market.
The forward has a decision to make on his future, and the Lakers are trying to make it easy for him.
United remains unbeaten in the league this season.
The Spaniard's team went top of the Premier League after beating Watford 6-0 at Vicarage Road on Saturday.
Talk ahead of this season was whether Sergio Aguero was being eased out at City, unthinkable though it was.
Sanchez and Raheem Sterling could swap clubs.
The Chilean forward is heading into the final year of his contract and Pep Guardiola will make one more attempt to sign him before the transfer window closes.
Manchester City beat Real Madrid 4-1 on Wednesday night.
Premier League clubs' spending is far from over.