The president's approval rating stood at 43 percent while almost 53 percent of Americans said they disapproved of his performance.
The former vice president has a larger lead over the Vermont senator among state voters who have already cast their ballots.
The state traditionally votes Republican in presidential contests.
The former vice president boasted his biggest lead over the senator in Florida, where 65 percent of likely primary voters backed him.
A little more than half of Americans told pollsters they did not trust the president to be honest about COVID-19's potential impact.
A new poll by Quinnipiac University shows former Vice President Joe Biden leading Sen. Bernie Sanders, 54 percent to 35 percent nationally, although more respondents said Sanders was honest.
Pollsters found that both the former VP and the Vermont senator were within the margin of error of overtaking Trump in Pennsylvania.
The frontrunners of the 2020 Democratic primary have both polled better against Trump than Clinton did at this time in 2016.
The Vermont senator had a clear lead among several demographics, but was only two points ahead of Biden among black voters.
The 2020 polls show Bernie Sanders leading President Donald Trump nationally, but how reliable are they months out from an election?
The survey by Ipsos found that a plurality of boomers felt their generation had a positive impact on modern American society.
Former Vice President Joe Biden's lead over Vermont Senator Bernie Sanders in South Carolina is less than five percentage points according to new polling data, two days before a primary Biden's campaign was expecting to win.
Senator Bernie Sanders is topping the Democratic field with 31 of percent support.
A majority of polled Democrats said the Vermont senator was best-placed to be the candidate to unify the party, despite suggestions that he would be divisive.
The Vermont senator was backed by 24 percent of poll respondents while Joe Biden was down 15 points from his September rating.
Bernie Sanders saw an increase of 4 percentage points since the Las Vegas Democratic debate last week; Elizabeth Warren was the only other candidate to see an increase.
The results showing most Democratic voters believed Sanders would beat Trump in the general election were released three days before the Nevada caucuses.
The former New York City mayor has seen his polling with black primary voters jump two points despite controversy around his past remarks on stop-and-frisk.
The new poll found the Vermont senator was the only Democratic primary candidate to beat Donald Trump in a hypothetical head-to-head.
A progressive polling firm found the Vermont senator had a huge lead among Hispanic likely caucus-goers in the state.
Joe Biden told a New York City fundraiser that the "African-American community is going to make a gigantic say in who is going to be the next president."
Spencer Kimball of Emerson told Newsweek that Sen. Klobuchar had a better chance of performing well in South Carolina than Pete Buttigieg.
One poll found the Minnesota senator was 7.6 points better off in New Hampshire following her debate performance on Friday.
The poll results from Gallup also show the president's approval rating broke records in terms of polarization.
Senator Bernie Sanders vowed to erase President Donald Trump's immigration policies, while a poll released Monday showed him leading the field of Democratic nominee hopefuls in New Hampshire.
Jim Messina, Obama's 2012 campaign manager, told an MSNBC panel that Senator Bernie Sanders was "the worst candidate" to beat Donald Trump in a general election.
President Donald Trump took to Twitter to declare "NO PRESSURE" as Democrats presented opening arguments in the Senate impeachment trial on Wednesday.
And fewer than half can name how Hitler came to power.
President Donald Trump urged his Twitter followers to "READ THE TRANSCRIPTS!" Tuesday, while a survey taken a week before the Senate impeachment trial began indicates Republican support for Trump has fallen slightly.