Arsenal takes on Spurs in the first North London derby of the season with both teams looking to bounce back from defeats suffered last week.
Liverpool travels to Burnley on Saturday hoping to maintain its perfect Premier League record.
Manchester City looks for a first home win of the season in the Premier League when it takes on Brighton on Saturday.
Having secured his first win as Chelsea manager last week, Frank Lampard looks to pick up three points at Stamford Bridge for the first time on Saturday.
After suffering a first defeat of the season last weekend, Manchester United travels to Southampton looking to get back to winning ways.
Manchester City looks to get back to winning ways after being denied a last-minute winner against Tottenham by VAR.
Mauricio Pochettino's men look for a second home win of the season on Sunday and could deepen Newcastle's woes.
Manchester United will be looking for a second consecutive home win when it takes on Crystal Palace this Saturday.
The two Premier League leaders meet at Anfield as Liverpool host Arsenal with both sides looking to extend their perfect record.
Chelsea travels to Norwich in the early game on Saturday looking for a first Premier League win under Frank Lampard.
Ole Gunnar Solskjaer's team travels to Wolverhampton looking to make it back-to-back wins in the first two games of the season.
Chelsea hosts Leicester City looking to bounce back from the opening day drubbing against Manchester United.
The Premier League champions host Tottenham on Saturday afternoon hoping to make it two wins in two.
Liverpool travels to Southampton looking to make it two wins in two Premier League games after thrashing Norwich City last time out.
Arsenal hosts Burnley on Saturday, looking to win the opening two fixtures of a Premier League games for the first time since 2009.
After a difficult summer, Manchester United and Chelsea kick off their Premier League campaigns at Old Trafford on Sunday.
After spending big in the summer, Arsenal kicks off its Premier League campaign against Newcastle on Sunday.
Spurs have made a major statement of intent with three signings this summer, while Villa returns to the top flight for the first time in two seasons.
The reigning Premier League champions begin their quest for a third title in a row when they take on West Ham on Saturday.
Fixtures for next season were released on Wednesday.
The title and relegation have already been decided but there is still intrigue to be found.