Royal Caribbean's new ship weighs over 200,000 tonnes and is 1,188 feet long. It has capacity for 6,988 guests and 2,300 crew members.
The CDC has advised U.S. citizens against going on cruises due to rising coronavirus cases.
The CDC advised Americans to avoid cruises as COVID cases rise across the country, because Omicron could be highly transmissible in the confines of a ship.
Ninety-eight percent of those who tested positive were vaccinated, and they have so far experienced only mild or no symptoms.
In April, the state of Florida sued the CDC, saying that Congress had never granted it the authority to regulate health and safety standards on cruise ships.
"Effective June 29, 2021, unvaccinated guests 12 and older departing on a Royal Caribbean International cruise from Florida are required to purchase travel insurance," a spokesperson for Royal Carribean wrote to Newsweek.
"Guests eligible but not fully vaccinated or able to show proof of vaccination will be subject to testing and additional health protocols at their own expense," the company said. "Children not eligible for vaccines will be subject to complimentary testing and health protocols."
The maiden cruise of Odyssey of the Seas, the line's newest vessel, has been pushed back to July 31 "out of an abundance of caution."
While travelers will have a difficult time finding cruise ship voyages departing from the U.S, they can find trips in other regions of the world.
All volunteers must be at least 18 years old and be either fully vaccinated or provide documentation that they are not at high risk of severe COVID-19 illness.
COVID-19 vaccinations will be required on the upcoming sailings from the Bahamas and St. Maarten, the company said.
One piece of litigation described Royal Caribbean's decision to allow visitors to the volcanic island "so reckless that it should not be tolerated in civilized society."
Several major cruise lines—Royal Caribbean, Carnival, Celebrity Cruises and Crystal Cruises—have announced cancellations or changes to their itineraries for cruises in March and April.
Royal Caribbean announced that anyone holding a passport from China, Hong Kong or Macau would be unable to board any of its ships throughout February.
Salvatore Anello has appeared again in Puerto Rico court charged with the negligent homicide of granddaughter Chloe Wiegand.
Chloe Wiegand fell to her death from aboard the Royal Caribbean's Freedom of the Seas in July while it was docked in Puerto Rico.
At least six people have died, another eight are missing and 31 are injured after the volcano on White Island, erupted off the coast of New Zealand.
Passengers from Royal Caribbean's Ovation of the Seas had been visiting the island the volcano erupted on New Zealand's Whakaari (White Island).
Salvatore Anello gives his first interview since being charged over the death of 18-month-old Chloe Wiegand in July.
Salvatore Anello has denied being responsible for the death of his granddaughter Chloe Wiegand in July.
Parents of Chloe Wiegand have always maintained Salvatore Anello is not responsible for the child's death in July.
Salvatore Anello, 50, was arrested by Puerto Rico police and charged with negligent homicide over the tragic death of Chloe Wiegand on the Royal Caribbean's Freedom of the Seas.
The body of the Royal Caribbean crew member was recovered from the water after he fell from its cruise ship "Rhapsody of the Seas."
The Royal Caribbean cruise ship picked up the Cubans in a broken raft as they were trying to reach Florida.
The unnamed Australian man was found in the water and taken back to the ship during a cruise in the Caribbean.
As Royal Caribbean's "Freedom of the Seas" cruise ship leaves a port without a couple who missed boarding, a crew member waves at the pier with a giant fake hand that says "bye."
Bernadette Chua wrote: "Do we really want to lock every window on a cruise ship?"
The passenger aboard a Royal Caribbean cruise ship is suing the company for negligence after she was allegedly brutalized by a gang of men.