The Seahawks could clinch a playoff spot with a win over their NFC West on Sunday night, while the Rams need a win to keep their playoff hopes alive.
New Orleans is the only team to have qualified for the playoffs so far, but Baltimore, New England, Kansas City, San Francisco and Seattle can join it on Sunday.
The remaining schedule includes a slew of games that will go a long way to determine not only which teams make the playoffs, but playoff seedings and home teams as well.
The Baltimore Ravens took control of the AFC with a 20-17 over San Francisco, which saw the 49ers slip to fifth in the NFC.
David Moore's touchdown reception put the Seahawks ahead by nine points, and he lined up with receivers Tyler Lockett and Jaron Brown for a synchronized boy band dance that had social media buzzing.
Seattle could draw level with the San Francisco 49ers at the top of the NFC West with a win over the Vikings on Monday night.
The New Orleans Saints became the first team to clinch a playoff spot this season with a 26-18 win over the Atlanta Falcons on Thanksgiving.
Week 13 features three games on Thanksgiving Day, while the New England Patriots face the Texans in Houston on "Sunday Night Football."
The Patriots and the Ravens are in control of the AFC, while the race for the NFC has got tighter after Seattle beat San Francisco on Monday Night Football.
The San Francisco 49ers look to improve to 9-0 when they host the Seattle Seahawks in a potentially crucial NFC West matchup.
The San Francisco 49ers are the only team left undefeated as the NFL season enters the second half, while the Patriots remain in charge of the AFC.
The 49ers are off to their best start in almost three decades, while the Packers and the Saints look nailed-on to reach the playoffs.
The Seahawks are 4-1 for only the second time in a decade and have a relatively easy schedule ahead of them.
Week 5 of the NFL regular season begins with an NFC West rivalry as Seattle hosts the Rams on Thursday night.
The Chargers host the Seattle Seahawks on Saturday night looking for a first win in three preseason games.
The two NFC rivals go head-to-head in Minneapolis on Sunday looking to make it two consecutive wins in preseason.
Russell Wilson's new agreement with the Seattle Seahawks tops Aaron Rodgers, who previously held the title for the highest-paid player in the NFL.
Perry joins a long list of NFL players who have suffered concussions in their career.
Sherman signed a three-year deal with the San Francisco 49ers on March 10.
There's no Sunday Night Football, but still plenty to watch.
Richard Sherman, one of the league's most charismatic players, suffered a season-ending injury in the latest Thursday game.
The Chiefs beat the Redskins on Monday night.
While some applauded Linsey, a former finalist on "The Voice" in Season 8, for showing solidarity with protesters for social equality, many in the country music singer's fan base were not pleased.