Some Republican senators have already declared they would not seek re-election in 2022, leaving those Senate seats up for grabs.
Eliminating the controversial Senate rule would greatly help push the Biden administration's agenda forward.
The Senate minority leader made the comments while arguing the case for keeping the legislative filibuster.
The GOP senator suggested that a trial could be prolonged if Democrats call witnesses, as Republicans would in turn want to do the same.
"It is extraordinarily unlikely the president will be convicted," Republican Maine Senator Susan Collins told reporters on Tuesday.
Forty-five Republicans went on record saying they don't view the trial as constitutional, effectively removing almost any doubt that a two-thirds majority will convict.
"We're keeping all our options open, on the table," Senate Majority Leader Chuck Schumer said about the $1.9 trillion COVID-19 relief bill, "including budget reconciliation."
"The rise of political careerism in today's Congress is a sharp departure from what the Founders intended," the Texas Republican said.
Senators Mitt Romney, Susan Collins, Lisa Murkowski, Ben Sasse and Patrick Toomey joined their Democratic counterparts in voting to table a motion to dismiss former President Donald Trump's impeachment trial.
"The differences [within the Republican Party] are not irreconcilable at all," Senator Rob Portman told Fox News.
The president faces the task of squeezing his agenda through the Senate, with the 50/50 split potentially proving an issue.
No president has ever faced an impeachment trial in the Senate after leaving office but that may not matter.
The Democratic senator suggested McConnell's actions were only a "first test" for Democrats in the upper chamber.
The House voted 232-197 to charge Donald Trump with "incitement of insurrection" in connection with the assault on the U.S. Capitol.
If former President Donald Trump is convicted in the Senate impeachment trial, the Senate could vote to prohibit Trump from holding a public office in the future.
Most experts believe that $1,400 stimulus checks are likely to pass, but Americans may have to wait past March to actually receive the checks due to disagreements in Congress.
Donald Trump is the only president in U.S. history to be impeached twice, but some things will change will this Senate trial.
GOP senators Richard Burr of North Carolina and Pat Toomey of Pennsylvania have also said they won't run again in 2022.
"It really depends on what the justification is," GOP Senator Bill Cassidy said of President Joe Biden's COVID-19 relief package.
Jason Miller said there were no active plans, but left open the prospect a new party on the right.
The Republican former governor said that GOP lawmakers want to "make political points with those people who the president and others lied to."
Stanford Professor David Kennedy said Hawley gave "credence to the patent falsehood that the election was 'rigged.'"
"I think it's pretty clear that over the last year or so there has been an effort to corrupt the election of the United States," the Republican senator said.
"Healing and unity will only come if there is truth and accountability," Senate Majority Leader Chuck Schumer said Friday, "and that is what this trial will provide."
"The people want action, not excuses," the Vermont senator said.
The New York representative said the Republicans should be chucked out of the Senate if they failed to resign.
Lawyer, dentist and conspiracy theorist Orly Taitz claims that the conviction of former President Donald Trump in a second impeachment trial would deprive her and others of a "Constitutional First Amendment right for the political speech, namely, to vote for Donald Trump in future elections."
"I do believe very strongly that we cannot just accept what happened here," the Democratic congressman told CNN.
Both political parties have made changes to the filibuster in the past, but now some Democrats want it gone completely.