Researchers estimate there are nearly 30,000 pythons in the Florida Everglades, and most grow to be 8 to 10 feet long.
Officials have warned people in the Carolinas to be on the lookout for snakes during Hurricane Florence flooding.
"The reptiles were in canisters, packed in bags, carried in hand luggage," environmental authorities said, after discovering the snakes when the plane landed.
It's not quite Jurassic Park, but the finds reveal "critical" clues about the evolutionary history of the slithery beasts.
"This made for one of the most impressive radiographs I have seen," the vet that dealt with the animal said.
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Authorities found 10 venomous snakes and two dead cobras in the home of Brandon Joseph Boyles, a snake vlogger.
The man called the 8-foot python "Tiny."
It was captured along a busy road.
Police said the reptile was "not fond" of the officers' attention.
Unfortunately the animal is already considered critically endangered.
The snakes have endured the "greatest modern decline of any native reptile."