F.W. de Klerk said that he was "deeply disappointed" in the scandal-dogged leader.
The country's former energy minister secretly signed an agreement with Russia's state nuclear firm in 2014.
If she had stayed, she says, "probably by now I'd be dead and buried."
The artist said that the painting depicts Zuma's "molesting" of South Africa.
Two of the three major ratings agencies have downgraded South Africa to junk status; only Moody's has not, yet.
Zuma turned 75 on Wednesday.
The image shows President Zuma and the Gupta family abusing a woman who represents the country.
Zuma recently fired his popular finance minister, sparking widespread criticism and a credit downgrade for South Africa.
An international ban on trading rhino horn remains in place.
Gigaba has promised to radically transform South Africa's economy, after its credit rating was just downgraded to junk status.
Helen Zille tweeted that colonialism wasn't entirely bad and suggested she saw it as bringing some benefits.
The president fired his popular finance minister to widespread criticism.
Opposition parties have filed motions of no confidence in the president.
The ANC's top brass is divided on whether Zuma should fire the finance minister.
Zuma is not attending "in compliance with the family's wishes."
The 87-year-old was a close friend of Nelson Mandela and spent 18 years on Robben Island.
A gang has been posing as taxi drivers, picking up and raping unsuspecting women.
Robbers disguised as police stole foreign currency from a Johannesburg airport.
Helen Zille claimed that colonialism was not entirely negative.
Party document acknowledges that it faces 'declining fortunes' among voters.
The criminals drove a marked vehicle and reportedly stole millions of dollars.
It's the latest sign of a rift in the ANC as it mulls its next leader.
After a series of engine fires, the American auto company has recalled 4,500 cars in South Africa. But some say there are still vehicles on the road that could put lives at risk.
Barclays, HSBC and JPMorgan Chase are among those accused.
It will be the first time soldiers have been used to guard parliament.