They last met in a Grand Slam final in 2011.
Wawrinka won his first Grand Slam at 28.
Wawrinka, the world number four, has a good head-to-head record against Murray.
Novak Djokovic's coach didn't like the world number two casting doubt on the sport.
The Spaniard eventually progressed to the quarter-finals.
As the tournament enters its second week, temperatures remain high and the stakes get higher.