The Senate majority leader's remarks implied that he does not expect ongoing talks between Nancy Pelosi and Steven Mnuchin to yield a bipartisan deal during the lame-duck session.
Facing a tough battle with Democratic contender Jaime Harrison, the South Carolina senator said his number-one priority, if he got elected, was another coronavirus stimulus package.
"The whole country is desperate for a second stimulus, but Republicans fled the Senate the moment they got their anti-everybody justice confirmed," Congresswoman Alexandria Ocasio-Cortez said.
Nancy Pelosi said Democrats won't accept a bill now that is smaller than their $2.2 trillion demand and then dole out more relief if Biden takes office in January.
The House speaker has pushed Treasury Secretary Steve Mnuchin for answers on outstanding questions the Democrats have on "critical" issues.
The deadline to pass the next federal budget falls on December 11. Congress must approve another spending bill by that date to avoid a shutdown and lawmakers could seize on the window to approve a stimulus package.
As of Wednesday afternoon, the S&P 500 dropped 3.2 percent, nearing its worst day in nearly two months.
Imminent GDP data is expected to present the biggest rebound for output since World War II. But experts say the main driver of the size and timing a potential future stimulus package will be political.
"Trump can't get his own party to deliver real economic relief for working families," Democratic Presidential Nominee Joe Biden said on Saturday morning.
"We could do that before the election if the president wants to. I think he does. I know we do," the Democratic House Speaker said.
"By the end of year, millions more Americans will have run out of jobless aid and have no access to federal extended benefits," one political think-tank wrote.
The same proposal was blocked by Democrats last month. The vote came as Nancy Pelosi and Steven Mnuchin continue to negotiate a costly comprehensive bill that many Senate Republicans have bemoaned.
The House speaker said that Trump needs the legislation and that while the Democrats also want the checks, they can't abandon other provisions of a relief bill.
Trump took slightly more of the blame than Pelosi in a 45 to 44 percent split.
While President Donald Trump has long been at odds with Democrats over a further relief package, he now faces clashing with lawmakers within his own party.
Senate Majority Leader Mitch McConnell cautioned against doing a large package but Trump wasn't worried about having enough support for another round of relief.
The Senate Majority Leader reportedly told Republican colleagues about the warning during a private lunch on Tuesday,
56 percent of Republicans supported a relief bill with a $2 trillion price tag, 34 percent opposed and 9 percent were unsure.
The vote came as House Speaker Nancy Pelosi and Treasury Secretary Steven Mnuchin were engaged in intense negotiations over a broader stimulus package.
The Republican did not indicate whether the vote would come before the upcoming presidential election.
"We all want to get an agreement because people need it...and our economy needs it,"" said the Speaker of the House Tuesday.
The president says he wants to spend even more than the $2.2 trillion that House Democrats have proposed for a coronavirus relief bill.
Even if stimulus negotiators can reach an agreement, GOP Senate leaders are doubtful they could muster the minimum support needed among their own members to pass legislation somewhere around $2 trillion.
Future contracts for the Dow Jones rose 79 points, while the futures for the S&P 500 and tech-heavy Nasdaq Composite edged higher into positive territory.
Democrats and Republicans agree on another round of stimulus checks, but passing a slimmed-down relief package may not mean a second distribution of the direct payments.
The Treasury Secretary has been tasked by the president to end the stalemate and secure a bipartisan agreement, as Election Day nears.
What's the most critical move the next president should make to restore the country's economic health? Newsweek asked 12 top financial experts to offer the next occupant of the White House their best advice.
The Speaker of the House said she is "optimistic" about negotiations, noting that "we've been back and forth on all of this."
The South Carolina senator said he supports another round of $1,200 stimulus checks.
The stimulus package is scheduled to be voted on in the Senate Wednesday, though it will be a $500 billion proposal.