The two divisional rivals collide on Sunday with the NFC West title and the No. 1 seed in the NFC on the line.
Five teams clinched a postseason berth in Week 15 and three divisions can be decided this weekend, with the Packers, Cowboys and Texans all within reach of divisional titles.
Buffalo could clinch a playoff spot with a win in Pittsburgh, while the Steelers can leapfrog the Bills in the race for a wildcard spot.
The San Francisco 49ers look to clinch a playoff spot after re-taking control of the NFC, while Houston faces a difficult trip to Tennessee.
The Seahawks could clinch a playoff spot with a win over their NFC West on Sunday night, while the Rams need a win to keep their playoff hopes alive.
The Baltimore Ravens have taken control of the AFC and the New Orleans Saints could overtake the San Francisco 49ers on Sunday.
New England could qualify for the playoffs for the 11th consecutive season with a win in Houston, as long as the Raiders fail to beat the Chiefs.
Week 13 features three games on Thanksgiving Day, while the New England Patriots face the Texans in Houston on "Sunday Night Football."
The 9-1 49ers host the 8-2 Packers in a game with potentially huge implications for the NFC playoffs.
Week 12 begins on Thursday night with a crucial AFC South matchup as the Houston Texans host the Indianapolis Colts.
Two struggling teams and two struggling offenses meet in Los Angeles as the Rams and the Bears look to keep their faint playoff hopes alive.
Week 11 begins on Thursday night with a crucial AFC North matchup as the Cleveland Browns host the Pittsburgh Steelers.
The Cowboys look for a third straight win when they host the Vikings, while Minnesota hopes to rebound from loss to Kansas City.
The San Francisco 49ers are the only team left undefeated as the NFL season enters the second half, while the Patriots remain in charge of the AFC.
The reigning Super Bowl champions are 8-0 for only the third time in franchise history but face their hardest test of the season to date.
Week 9 of the NFL begins on Thursday when the San Francisco 49ers look to make it 8-0 when they take on the Cardinals in Arizona.
The Aaron Rodgers vs. Patrick Mahomes showdown is unlikely to materialize as the Kansas City Chief is struggling with a knee injury.
The reigning NFL MVP dislocated his kneecap against the Broncos last week but has already returned to practice.
Week 8 of the NFL regular season begins on Thursday when the Minnesota Vikings host the Washington Redskins.
The Eagles travel to Dallas in a potentially crucial divisional matchup, with both teams top of the NFC East.
The Kansas City Chiefs open Week 7 when they take on the Denver Broncos on the road on Thursday Night Football.
The Chargers look to get back to .500 with a win against Pittsburgh, while the Steelers need a win to keep their slim playoffs hopes alive.
Week 6 of the NFL regular season kicks off on Thursday when the New York Giants travel to New England to face the Patriots.
The Chiefs host the Colts in a rematch of last season's AFC Divisional Round Playoffs as they look to improve to 5-0.
The Cowboys are 3-0 for the first time in 11 years and will look to lay down a marker in New Orleans against the Saints.
Week 4 of the NFL regular season kicks off on Thursday when the Philadelphia Eagles travel to Green Bay to face the Packers.
The Cleveland Browns look to improve to 2-1 when they host the Los Angeles Rams, who are seeking a third consecutive win.
The Eagles travel to Atlanta looking to make it back-to-back wins, while the Falcons must avoid a second consecutive loss.
The Patriots begin their quest for a seventh Super Bowl ring when they host the Steelers in Foxborough on Sunday night.