Serena Williams will face off against Roberta Vinci of Italy at 11 a.m. ET on Friday.
On Tuesday evening, Serena defeated Venus and Djokovic prevailed against Lopez to advance.
The quarterfinals begin without Andy Murray, who exited the tournament in an upset Monday.
As the tournament enters its second week, temperatures remain high and the stakes get higher.
A record number of players have already had to retire from the tournament.
The Swiss tennis player is a transcendent moral force in a world of blood, sweat and brute effort according to his fans
The Australian-born Hewitt, 75, was found guilty of assaulting three under-age girls during his time coaching children in South Africa in the 1980s and 1990s.
"Let's do this!" tweeted the Wimbledon champion on polling day after previously refusing to be drawn on the vote
A string of monumental upsets facilitated the unlikely final, only the second this century to feature two seeds ranked No.10 or below
As his country courts the EU, the tennis star is mending its damaged reputation, one Grand Slam at a time
Maria Sharapova has been the highest-paid female athlete in the world 10 years in a row. Here's why.