Five teams clinched a postseason berth in Week 15 and three divisions can be decided this weekend, with the Packers, Cowboys and Texans all within reach of divisional titles.
Jackson broke Michael Vick's record for rushing yards in a single-season by a quarterback, taking his season tally to 1,107.
The Ravens look to make it 10 consecutive wins and consolidate their chances of securing top spot in the AFC on Thursday night.
The San Francisco 49ers look to clinch a playoff spot after re-taking control of the NFC, while Houston faces a difficult trip to Tennessee.
Dallas looks to snap a two-game losing streak and consolidate its lead in the NFC East when it takes on the 6-6 Bears in Chicago.
The Baltimore Ravens have taken control of the AFC and the New Orleans Saints could overtake the San Francisco 49ers on Sunday.
The NFL's triple-header on Thanksgiving last year saw the fourth most wagers placed on a sporting event in the U.S. in 2018.
The NFL's Thanksgiving tradition continues this year, as the Lions host the Bears and the Cowboys welcome the Bills, while the Saints take on the Falcons.
The holiday's traditional football bonanza sees three games on the slate this Thursday, as the Lions host the Bears, the Cowboys welcome the Bills and the Saints take on the Falcons.
Week 13 features three games on Thanksgiving Day, while the New England Patriots face the Texans in Houston on "Sunday Night Football."
The two AFC South rivals both enter Week 12 with a 6-4 record ,and their matchup in Houston will have major implications for the playoffs picture.
Week 12 begins on Thursday night with a crucial AFC South matchup as the Houston Texans host the Indianapolis Colts.
Week 10 of the NFL begins in Cleveland where the Browns host the Pittsburgh Steelers on Thursday night.
Week 11 begins on Thursday night with a crucial AFC North matchup as the Cleveland Browns host the Pittsburgh Steelers.
Week 10 of the NFL begins in Oakland where the Raiders host the Los Angeles Chargers on Thursday night.
The San Francisco 49ers are the only team left undefeated as the NFL season enters the second half, while the Patriots remain in charge of the AFC.
Week 9 of the NFL begins in Arizona, where the Cardinals host the San Francisco 49ers on Thursday night.
Week 9 of the NFL begins on Thursday when the San Francisco 49ers look to make it 8-0 when they take on the Cardinals in Arizona.
Week 8 of the NFL begins in Minneapolis, when the Vikings host Washington hoping to make it four wins in a row.
Week 8 of the NFL regular season begins on Thursday when the Minnesota Vikings host the Washington Redskins.
The reigning NFL MVP suffered a dislocated kneecap after he was injured on a quarterback sneak on Thursday night.
The Kansas City Chiefs face AFC West rivals Denver Broncos as they look to snap a two-game losing streak.
The Kansas City Chiefs open Week 7 when they take on the Denver Broncos on the road on Thursday Night Football.
Week 6 of the NFL regular season kicks off on Thursday night, when the Patriots host the Giants in Foxborough looking to improve to 6-0.
The star running back was thought to be in contention for Thursday night's trip to Foxborough but will miss the game.
Week 6 of the NFL regular season kicks off on Thursday when the New York Giants travel to New England to face the Patriots.
The Seahawks are 4-1 for only the second time in a decade and have a relatively easy schedule ahead of them.
Week 5 of the NFL regular season begins with an NFC West rivalry as Seattle hosts the Rams on Thursday night.
The Eagles are in a precarious position at 1-2, while Green Bay hopes to make it four straight wins on Thursday.
Week 4 of the NFL regular season kicks off on Thursday when the Philadelphia Eagles travel to Green Bay to face the Packers.