Recent moves in the Republican-controlled House suggest a thaw.
Clinton's opposition to the deal reflects the Democratic Party's shift to the left and the changing politics of trade in both parties.
"I am afraid this deal appears to fall woefully short," said Republican Senator Orrin Hatch.
The sweeping deal could influence everything from the price of cheese to the cost of cancer treatments.
The fight for the almost-dead trade deal is not an easy one.
Despite last-minute lobbying, legislation needed to pass the Trans-Pacific Partnership failed on Friday.
The short answer: a giant trade agreement between the U.S. and 11 other nations. The long answer: We don't know.
The president's social media launch went smoothly enough.