The Canadian-born player picked up her third-straight, three-set upset win when she defeated No. 5 Elina Svitolina in the quarterfinals Tuesday.
Osaka said she is "going to take a break from playing for a while" following her loss to Leylah Fernandez.
Alexander Zverev may also fancy his chances with no Rafael Nadal at Flushing Meadows.
The former Fox News host found a way to offend tennis fans and those connected with the U.S. military.
The Spaniard won his maiden major after shooting 4-under par in the final round at Torrey Pines on Sunday.
The reigning PGA Championship winner shot 4-over par in the opening round, while three-time major winner Jordan Spieth finished at 6-over par.
Russell Henley and Louis Oosthuizen lead the way at Torrey Pines, with Brooks Koepka and Jon Rahm two shots adrift.
From his early triumphs to his latest tragedy, Tiger Woods has become a household name. Here's a pictorial journey of his successes from budding superstar to a golfing legend—and tragedies in between.
World No. 1 Dustin Johnson is the man to beat in the second major of the season, with No. 2 Jon Rahm and No. 7 Xander Schauffele among his leading rivals.
The 22-year-old tennis superstar plans to honor the memory of others who have died to raise awareness about racial injustice and Black Lives Matter.
The world No. 1 competed in the Adria Tournament last week, but the final was canceled after a number of players tested positive to COVID-19.
Serena Williams looks for a record-equalling 24th Grand Slam title, while Bianca Andreescu could become the first Canadian to win a major.
Rafael Nadal takes on Matteo Berrettini on Friday night looking for a second U.S. Open final in three years.
Serena Williams looks for a second consecutive U.S. Open Final when she plays No. 5 seed Elina Svitolina on Thursday night.
The Spaniard is odds-on favorite to win a 19th Grand Slam title after Novak Djokovic and Roger Federer were both knocked out.
Federer chases a first semifinal at Flushing Meadows since 2015, while Williams looks to take another step towards a 24th Grand Slam title.
Nadal takes on 2014 U.S. Open winner Marin Cilic while Osaka plays No. 13 seed Belinda Bencic on Monday.
"These people are here for you. You're amazing," Osaka told Gauff before their viral post match joint interview.
Federer takes on Britain's Dan Evans, while Djokovic faces American qualifier Denis Kudla on Friday evening.
Coco Gauff plays Hungary's Timea Babos, while Rafael Nadal takes on Australia's Thanasi Kokkinakis on Thursday.
The world No. 1 and the world No. 3 are both in action on Wednesday, as are the Williams sisters.
Rafael Nadal and Coco Gauff are both in action on Tuesday as the first round of the U.S. Open is completed.
The teenager crashed out of the Citi Open in Washington, D.C., after losing in straight sets to Kazakhstan's Zarina Diyas.
The 15-year-old's dream run came to an end on Monday, but she was won numerous new fans along the way.
Brooks Koepka is the bookmakers' favorite as the third major of the year gets underway on Thursday at Pebble Beach, California.
Woods ended an 11-year wait for a major in April when he won The Masters, but can he repeat the feat at Pebble Beach?
At 15/2, Koepka is the bookies' favorite to win the U.S. Open for the third consecutive year, while Tiger Woods is at 9/1.
Brooks Koepka could become the first man in 114 years to win the U.S. Open three times in a row if he wins at Pebble Beach this weekend.
Woods has now missed the PGA Championship cut three out of his last four tries, and Brooks Koepka is cruising as the clubhouse leader by seven strokes.